Reacción #1375000

Ecuación de reacción

4,5-dimethylthiazole 2-thiolcarboxylic acid dicyclohexylamine salt

water

hydrochloric acid

→

4,5-Dimethylthiazole 2-thioicarboxylic acid

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe layers were separated
2. 2
   Extracciónthe aqueous phase was extracted with 2 × 75 ml
3. 3
   SecadoThe combined organic phases were dried over magnesium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated under reduced pressure
6. 6
   Otroyielding 4.6 g

Procedimiento

11.7 g. (0.033 mole) of 4,5-dimethylthiazole-2-thiolcarboxylic acid dicyclohexylamine salt, dissolved in 175 ml. of water and 175 ml. of ethyl acetate, was cooled and acidified with 6N hydrochloric acid to pH 2.2. The layers were separated and the aqueous phase was extracted with 2 × 75 ml. of ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and evaporated under reduced pressure yielding 4.6 g. (80%) of a red solid. Infrared spectrum was consistent with the desired material.

Fuente