Reacción #1371

Ecuación de reacción

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

Rendimiento 82.6%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is refluxed for 2.5 hours
2. 2
   TemperaturaAfter cooling
3. 3
   Extracciónthe resultant is extracted with diethyl ether
4. 4
   Secadothe extract is dried over magnesium sulfate
5. 5
   Concentraciónconcentrated

Procedimiento

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

Fuente