Reacción #1367

Ecuación de reacción

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

Rendimiento 71.3%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   Extracciónextracted with dichloromethane
4. 4
   SecadoThe is dried over magnesium sulfate
5. 5
   Concentraciónconcentrated

Procedimiento

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

Fuente