Reacción #1362241

Ecuación de reacción

methyl 4-nitrophenoxyacetate

hydrogen

→

title compound

Rendimiento 97.6%

Methyl 4-aminophenoxyacetate

Rendimiento 97.6%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAt the end of this time, the reaction mixture was filtered
2. 2
   Concentraciónthe filtrate was concentrated by evaporation under reduced pressure

Procedimiento

A solution of 30.8 g of methyl 4-nitrophenoxyacetate [prepared as described in step (a) above] in 500 ml of methanol was shaken in an atmosphere of hydrogen and in the presence of 5.0 g of 10% w/w palladium-on-charcoal for 6 hours. At the end of this time, the reaction mixture was filtered and the filtrate was concentrated by evaporation under reduced pressure, to give 25.8 g of the title compound having an Rf value=0.79 (on thin layer chromatography on silica gel; developing solvent: ethyl acetate).

Fuente