Reacción #1362

Ecuación de reacción

sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine

sodium hydroxide

→

N,N-bis(2,3-epoxypropyl)glycine

Rendimiento 84.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure, and 100 ml of ethanol
3. 3
   workup.ADDITIONwere added to the residue
4. 4
   Otroto separate insoluble matter
5. 5
   Filtraciónby filtration
6. 6
   workup.DISTILLATIONThereafter, ethanol was distilled off under reduced pressure

Procedimiento

A reactor was charged with 20 g (0.07 mole) of sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine obtained in the same manner as in Referential Example 1 and 100 g of water, and the contents were kept at 50° C., to which 35 ml of a 4N aqueous solution of sodium hydroxide were added. After the mixture was stirred for 30 minutes, the solvent was distilled off under reduced pressure, and 100 ml of ethanol were added to the residue to separate insoluble matter by filtration. Thereafter, ethanol was distilled off under reduced pressure, thereby obtaining 11 g (isolation yield: 84%) of N,N-bis(2,3-epoxypropyl)glycine.

Fuente