Reacción #1361685

Ecuación de reacción

3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine

2-chloro-acrylonitrile

→

3-(4-Cyano-1H-1,2,3-triazol-1-yl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISTILLATIONExcess 2-chloro-acrylonitrile is distilled off in vacuo
2. 2
   Filtraciónthe precipitated product is filtered off
3. 3
   Lavadowashed with water
4. 4
   Otrodried
5. 5
   Otro(yield 1.1 g; 87% of theory), m.p. 214-216° C. (recrystallization from ethyl acetate/toluene)

Procedimiento

A mixture of 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine (1.01 g) and 2-chloro-acrylonitrile (0.95 g) in water (5 ml) is stirred at about 80° C. for 18 hours. Excess 2-chloro-acrylonitrile is distilled off in vacuo, and the precipitated product is filtered off, washed with water and dried (yield 1.1 g; 87% of theory), m.p. 214-216° C. (recrystallization from ethyl acetate/toluene).

Fuente