Reacción #1350609

Ecuación de reacción

Copper(I) cyanide

4-bromo-2-fluorotoluene

→

title compound

Rendimiento 58.0%

2-fluoro-4-cyanotoluene

Rendimiento 58.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to room temperature
2. 2
   Otrothe mixture was partitioned between water and EtOAc (500 mL each)
3. 3
   SecadoThe organic layer was dried (MgSO4), and solvent
4. 4
   Otrowas removed under vacuum

Procedimiento

Copper(I) cyanide (Aldrich, 3.6 g, 40 mmol) was added to a solution of 4-bromo-2-fluorotoluene (Aldrich, 5 g, 27 mmol) in DMF (60 mL). The reaction mixture was heated at 150° C. for 11 hours. After cooling to room temperature, the mixture was partitioned between water and EtOAc (500 mL each). The organic layer was dried (MgSO4), and solvent was removed under vacuum to give the title compound (2.08, 58%). 1HNMR (CDCl3) δ2.36 (s, 3H), 7.30 (m, 3H), 7.35 (d, 1H, J=8.1 Hz).

Fuente