Reacción #1350594

Ecuación de reacción

EDC

2-methylamino-4-methylbenzothiazole-5-carboxylic acid

1-methyl-5-hydroxypyrazole

acetonitrile

→

1-Methylpyrazol-5-yl 2-Methylamino-4-methylbenzothiazole-5-carboxylate

Disolventes

water

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted with ethyl acetate
2. 2
   LavadoThe organic phase was washed
3. 3
   Otrodried
4. 4
   Otrothe product was then purified by crystallization

Procedimiento

3.1 g of 2-methylamino-4-methylbenzothiazole-5-carboxylic acid (0.014 mol) and 1.4 g of 1-methyl-5-hydroxypyrazole (0.015 mol) were dissolved in 110 ml of abs. acetonitrile and admixed with 2.67 g of EDC (0.014 mol), 1,2 ml of triethylamine and a catalytic amount of DMAP. After the reaction had ended, the solution was poured into water and the mixture was extracted with ethyl acetate. The organic phase was washed and dried, and the product was then purified by crystallization. Yield: 2.2 g (52%).

Fuente