Reacción #1350576

Ecuación de reacción

3-methoxyphenylacetyl chloride

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

Rendimiento 19.0%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl]-2-(3-methoxyphenyl)acetamide

Rendimiento 19.0%

Disolventes

dichloromethane

dichloromethane

brine

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe organic layer was washed with more brine
2. 2
   Secadothen dried over magnesium sulphate
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   OtroThe crude product was purified by column chromatography (ethyl acetate-toluene, 1:1)

Procedimiento

A solution of 3-methoxyphenylacetyl chloride (0.02 ml, 0.12 mmol) in dichloromethane (0.75 ml) was added dropwise at 0° C. to a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (0.02 ml, 0.13 mmol) in dichloromethane (0.75 ml). The resulting mixture was stirred at room temperature for 16 h and then poured into brine. The organic layer was washed with more brine then dried over magnesium sulphate and concentrated in vacuo. The crude product was purified by column chromatography (ethyl acetate-toluene, 1:1), giving the title compound (9 mg, 19%). Rf 0.30 (ethyl acetate-toluene, 1:1).

Fuente