Reacción #1336023

Ecuación de reacción

6-chloro-2-[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid

phosphorus oxychloride

N,N-dimethylaniline

→

1,6-dichloro-7-methoxy-4-nitro-9(10H)-acridinone

Disolventes

1,2-dichloroethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaunder reflux for 45 minutes
3. 3
   FiltraciónThe resulting solid was collected by filtration from the hot reaction mixture
4. 4
   Lavadowas washed with chloroform

Procedimiento

A mixture of 17 g of 6-chloro-2-[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid, 35 ml of phosphorus oxychloride, 1 ml of N,N-dimethylaniline and 150 ml 1,2-dichloroethane was heated under reflux for 45 minutes. The resulting solid was collected by filtration from the hot reaction mixture and was washed with chloroform to provide 1,6-dichloro-7-methoxy-4-nitro-9(10H)-acridinone, mp 284°-285° C.

Fuente