Reacción #1329169

Ecuación de reacción

sarcosine methyl ester hydrochloride

DBU

benzyl isothiocyanate

→

title compound

Rendimiento 99.9%

3-benzyl-1-methyl-2-thioxoimidazolidin-4-one

Rendimiento 99.9%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting solution was heated
2. 2
   Temperaturaat reflux 16 h
3. 3
   Temperaturacooled
4. 4
   Concentraciónconcentrated
5. 5
   Otrochromatographed (silica gel, DCM)

Procedimiento

To a solution of sarcosine methyl ester hydrochloride (0.56 g, 4.0 mmol) and DBU (0.60 mL, 4.0 mmol) in anhydrous ethanol added benzyl isothiocyanate (0.53 mL, 4.0 mmol). The resulting solution was heated at reflux 16 h, cooled, concentrated and chromatographed (silica gel, DCM) to give the title compound (0.88 g, quant.). 1H-NMR (CDCl3): δ 7.49–7.53 (2H, m), 7.28–7.35 (3H, m), 5.02 (2H, s), 4.03 (2H, s), 3.34 (3H, s).

Fuente