Reacción #1285238

ord-213fb1421ede44b9ae9770a2f7f4ac65

Ecuación de reacción

CCCCCCCCCCCCS(=O)(=O)CCCC(=O)O
4-(dodecylsulfonyl)butanoic acid
O=C(n1ccnc1)n1ccnc1
1,1'carbonyldiimidazole
[Cl-].[Cl-].[Mg+2]
magnesium chloride
C[CH2][K].O=C(O)CC(=O)O
ethyl potassium malonate
CCN(CC)CC
triethylamine
→
CCCCCCCCCCCCS(=O)(=O)CCCC(=O)CC(=O)OCC
title compound
CCCCCCCCCCCCS(=O)(=O)CCCC(=O)CC(=O)OCC
6-(dodecylsulfonyl)-3-oxo-hexanoic acid ethyl ester

Reactantes

CCCCCCCCCCCCS(=O)(=O)CCCC(=O)O
4-(dodecylsulfonyl)butanoic acid
O=C(n1ccnc1)n1ccnc1
1,1'carbonyldiimidazole
[Cl-].[Cl-].[Mg+2]
magnesium chloride
C[CH2][K].O=C(O)CC(=O)O
ethyl potassium malonate
CCN(CC)CC
triethylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared from 4-(dodecylsulfonyl)butanoic acid (H. Gilman, et al, J. Am Chem. Soc. 74, 4452 (1952)) (2.50 g, 0.07 mol), 1,1'carbonyldiimidazole (1.50 g, 0.09 mol), magnesium chloride (1.41 g, 0.014 mol), ethyl potassium malonate (2.12 g, 0.012 mol), and triethylamine (1.73 g, 0.017 mol) using the procedure described in Example 3, Step A.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05278326uspto-grants-1994_01