Reacción #1284743

ord-61158868cb274b298e955c99f7791fdf

Ecuación de reacción

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
COC(=O)CCc1ccc(N2CCN(C3CCNCC3)C2=O)cc1
1-[4-(2-methoxycarbonyl-ethyl)-phenyl]-3-(4-piperidinyl)-imidazolidin-2-one
Br.CCSC(=N)N
S-ethylisothiourea-hydrobromide
→
COC(=O)CCc1ccc(N2CCN(C3CCN(C(=N)N)CC3)C2=O)cc1
1-(1-Amidino-4-piperidinyl)-3-[4-(2-methoxycarbonyl-ethyl)-phenyl]-imidazolidin-2-one

Reactantes

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
COC(=O)CCc1ccc(N2CCN(C3CCNCC3)C2=O)cc1
1-[4-(2-methoxycarbonyl-ethyl)-phenyl]-3-(4-piperidinyl)-imidazolidin-2-one
Br.CCSC(=N)N
S-ethylisothiourea-hydrobromide

Reactivos

Ninguno

Disolventes

CN(C)C=O
dimethylformamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared from 1-[4-(2-methoxycarbonyl-ethyl)-phenyl]-3-(4-piperidinyl)-imidazolidin-2-one and S-ethylisothiourea-hydrobromide by heating to 100° C. for four hours in dimethylformamide in the presence of sodium carbonate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05276049uspto-grants-1994_01