Reacción #1284258

Ecuación de reacción

isopropanol

BOC-Arg

HCl

MeOH

→

H-Arg

Rendimiento 74.3%

Disolventes

HCl AcOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solution was reacted at room temperature for an hour
2. 2
   workup.ADDITIONwas added to the reaction mixture
3. 3
   Otroprecipitation again in AcOEt
4. 4
   FiltraciónThe precipitated crystals were taken by filtration
5. 5
   Otrodried

Procedimiento

BOC-Arg-CHA.HCl, 243.7 g (0.55 mole), was dissolved in 1093 ml of 2N HCl/AcOH and a small amount of MeOH. The solution was reacted at room temperature for an hour. After completion of the reaction, 1093 ml of isopropanol was added to the reaction mixture to cause precipitation again in AcOEt. The precipitated crystals were taken by filtration and dried to give 156.2 g (74.3%) of H-Arg-CHA.2HCl.

Fuente