Reacción #1275

Ecuación de reacción

sodium hydroxide

sulfuric acid

Trans-1,2-indandiol

acetonitrile

acetonitrile

Water

→

cis-1-amino-2-indanol

Rendimiento 63.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was gradually warmed to 20° C. and aged to 3 hours
2. 2
   Temperaturathe mixture heated to reflux
3. 3
   OtroThe resulting solid was removed by filtration

Procedimiento

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

Fuente