Reacción #1269863

Ecuación de reacción

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

Disolventes

Et2O

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe white cake was filtered
2. 2
   Lavadowashed with Et2O
3. 3
   Otrodried at HV overnight
4. 4
   OtroThe crude (1.19 g) was used without purification

Procedimiento

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

Fuente