Reacción #1269860

Ecuación de reacción

suspension

4-((S)-4-Carboxy-2-{[5-((E)-2-carboxy-vinyl)-2-phenyl-thiazole-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester

→

desired product

Rendimiento 33.8%

4-((S)-4-Carboxy-2-{[5-(2-carboxy-ethyl)-2-phenyl-thiazole-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester

Rendimiento 33.8%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction mixture was filtrated over celite
2. 2
   Otrothe filtrate evaporated to dryness

Procedimiento

A suspension of Example 19 (53 mg) and Pd/C (10%, 62 mg) in MeOH (2 mL) was stirred at RT under H2 atmosphere until reaction completion. The reaction mixture was filtrated over celite and the filtrate evaporated to dryness. Preparative HPLC (I) gave 18 mg of the desired product as yellow foam.

Fuente