Reacción #1269858

Ecuación de reacción

4-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester

→

desired compound

Rendimiento 94.9%

4-((S)-2-Amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester

Rendimiento 94.9%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered through celite
2. 2
   Otroevaporated off
3. 3
   OtroHV drying

Procedimiento

A suspension of 4-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester (4.00 g, prepared as described in WO2008050301) and Pd/C (5%, 0.42 g) in EtOH (15 mL) was hydrogenated at RT overnight. The reaction mixture was then stirred under H2 overnight. The mixture was filtered through celite and evaporated off. HV drying afforded the desired compound as light brown oil (2.79 g).

Fuente