Reacción #1269852

Ecuación de reacción

4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester

2-phenyl-1,3-thiazole-4-carboxylic acid

DIPEA

TBTU

→

desired product

Rendimiento 49.0%

4-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid ethyl ester

Rendimiento 49.0%

Disolventes

DMF

DMF

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction mixture was directly purified by preparative HPLC (IV)

Procedimiento

To a solution of 2-phenyl-1,3-thiazole-4-carboxylic acid (5.1 mg) and DIPEA (3 eq) in DMF (0.4 mL) was added TBTU (1.2 eq) in DMF (0.2 mL). Then, a solution of 4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester (5.4 mg, prepared as described in WO2006114774) in DMF (0.2 mL) was added. After stirring overnight at RT, the reaction mixture was directly purified by preparative HPLC (IV) to give 4.9 mg of the desired product.

Fuente