Reacción #1261646

Ecuación de reacción

lithium carbonate

8,9-dibromocyclohexadecanone

→

7,9-cyclohexadecadien-1-one

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe reaction was washed with 2 L water
2. 2
   workup.DISTILLATIONDistillation over caustic (2% NaOH )

Procedimiento

The crude 8,9-dibromocyclohexadecanone was fed into a reaction vessel containing a slurry of dimethylformamide (DMF) 700 ml and lithium carbonate (111 g 1.5 mole) at 150° C. The mass was aged for 14 hrs. The reaction was washed with 2 L water then 10% aqueous acetic acid (500 ml). Distillation over caustic (2% NaOH ) affords 54 g of 7,9-cyclohexadecadien-1-one and 86 g of a mixture of 8-cyclohexadecenone and 7,9-cyclohexadecadien-1-one.

Fuente