Reacción #1258

Ecuación de reacción

(-)-2-(4-(3-hydroxy-4,4,4-trifluoro-1-butenyl) phenyl)-5-decyloxypyrimidine

→

(-)-2-(4-(3-butoxy-4,4,4-trifluoro-1-butenyl)phenyl)-5-decyloxypyrimidine

Rendimiento 173.7%

Disolventes

butyl iodide

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction mixture was cleared of silver oxide by filtration
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   Otrothe residue was purified by silica gel column chromatography

Procedimiento

1.0 g of (-)-2-(4-(3-hydroxy-4,4,4-trifluoro-1-butenyl) phenyl)-5-decyloxypyrimidine was dissolved in 5 ml of butyl iodide. The solution was added with 3 g of silver oxide and stirred at 25°-30° C. for 4 days. The reaction mixture was cleared of silver oxide by filtration and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using toluene/ethyl acetate as eluent to obtain 0.98 g of (-)-2-(4-(3-butoxy-4,4,4-trifluoro-1-butenyl)phenyl)-5-decyloxypyrimidine.

Fuente