Reacción #1257

Ecuación de reacción

(-)-(4-(1-acetoxyethyl) phenyl)-5-decyloxypyrimidine

→

(-)-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine

Disolventes

methanol

sodium hydroxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrohydrolyzed, and the resulting reaction solution
2. 2
   Extracciónwas extracted
3. 3
   workup.ADDITIONby adding 200 ml of water and 200 ml of toluene
4. 4
   Otrofollowed by liquid separation
5. 5
   SecadoThe obtained organic layer was dried over anhydrous magnesium sulfate

Procedimiento

4 g of the above product (-)-(4-(1-acetoxyethyl) phenyl)-5-decyloxypyrimidine was dissolved in a mixture of 50 ml of methanol and 10 ml of a 20% sodium hydroxide solution, stirred at 30° C. for 2 hours and hydrolyzed, and the resulting reaction solution was extracted by adding 200 ml of water and 200 ml of toluene, followed by liquid separation. The obtained organic layer was dried over anhydrous magnesium sulfate and cleared of solvent in vacuo to yield 3.5 g of (-)-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine as a white solid.

Fuente