Reacción #1256751

Ecuación de reacción

ammonium chloride

Magnesium

iodine

diisopropylchlorosilane

1-Bromo-3-ethoxypropane

→

liquid

Rendimiento 107.4%

(3-Ethoxypropyl)diisopropylsilane

Rendimiento 107.4%

Disolventes

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe resultant mixture was extracted with pentane
2. 2
   Lavadoby washing with water six times
3. 3
   Secadodrying over sodium sulfate anhydrate
4. 4
   OtroThe solvent was removed under reduced pressure, whereby the Compound 61a

Procedimiento

1-Bromo-3-ethoxypropane (5.85 g, 35.0 mmol) was dissolved in THF (30 mL). Magnesium (900 mg, 37.0 mmol) and iodine (catalytic amount) were added thereto, and the resultant mixture was stirred at room temperature for 30 minutes and at 60° C. for 10 minutes. The resultant mixture was added dropwise to diisopropylchlorosilane (5.12 mL, 30.0 mmol) in THF (40 mL), followed by stirring at room temperature for 15 minutes and at 60° C. for 1.5 hours. Saturated aqueous ammonium chloride was added thereto, and the resultant mixture was extracted with pentane, followed by washing with water six times and drying over sodium sulfate anhydrate. The solvent was removed under reduced pressure, whereby the Compound 61a was obtained as an yellow liquid (6.52 g, 92%).

Fuente