Reacción #1256750

Ecuación de reacción

diisopropylchlorosilane

magnesium

iodine

ammonium chloride

1-Bromo-3-methoxypropane

→

liquid

Rendimiento 103.1%

Diisopropyl(3-methoxypropyl)silane

Rendimiento 103.1%

Disolventes

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGby stirring at room temperature for 1 hour
2. 2
   OtroAfter termination of exothermic reaction
3. 3
   ExtracciónThe resultant mixture was extracted with pentane
4. 4
   Lavadoby washing with water six times
5. 5
   Secadodrying over sodium sulfate anhydrate
6. 6
   OtroThe solvent was removed under reduced pressure, whereby the Compound 60a

Procedimiento

1-Bromo-3-methoxypropane (9.18 g, 60.0 mmol) was dissolved in THF (55 mL), and magnesium (1.53 g, 62.9 mmol) and iodine (catalytic amount) were added thereto, followed by stirring at room temperature for 20 minutes and at 55° C. for 5 minutes. The resultant mixture was added dropwise to diisopropylchlorosilane (8.88 mL, 52.0 mmol) in THF (65 mL) for 5 minutes, followed by stirring at room temperature for 1 hour. After termination of exothermic reaction, the resultant mixture was further stirred at 50° C. for 1.5 hours, and saturated aqueous ammonium chloride was added thereto. The resultant mixture was extracted with pentane, followed by washing with water six times and drying over sodium sulfate anhydrate. The solvent was removed under reduced pressure, whereby the Compound 60a was obtained as an yellow liquid (10.1 g, 89%).

Fuente