Reacción #1256734

Ecuación de reacción

[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile

di-terbutyl carbonate

Sodium borohydride

→

tert-butyl {2-[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]ethyl}carbamate

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONis added portionwise to the reaction mixture
2. 2
   Otrois allowed to room temperature

Procedimiento

The [1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile (4.76 mmol, 0.90 g), the di-terbutyl carbonate (9.52 mmol, 2.08 g) and nickel chloride hexahydrate (4.77 mmol, 1.13 g) are added to methanol (10 ml) at room temperature. Sodium borohydride (13.1 mmol, 0.49 g). is added portionwise to the reaction mixture. The reaction mixture is allowed to room temperature and stirred for three hours.

Fuente