Reacción #1253969

Ecuación de reacción

1-methylnaphthalene

HNO3

H2SO4

→

4-Nitro-1-methylnaphthalene

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction for one hour
2. 2
   Lavadowashed with water (3×), aqueous saturated NaHCO3 (2×) and brine
3. 3
   Secadodried over MgSO4
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe product was purified by silica gel column chromatography
6. 6
   Otrorecrystallized from methanol
7. 7
   Otroto give yellow needles

Procedimiento

To a cold (0° C.) suspension of 1-methylnaphthalene (5 g) in HNO3 was added H2SO4 (5 mL) dropwise. After stirring the reaction for one hour, the solution was diluted with ethyl acetate and washed with water (3×), aqueous saturated NaHCO3 (2×) and brine, dried over MgSO4, and concentrated. The product was purified by silica gel column chromatography using ethyl acetate:hexane (5:95) and recrystallized from methanol to give yellow needles.

Fuente