Reacción #1253196

Ecuación de reacción

3-Fluoro-4-(4-{2-fluoroethyl}-3-oxopiperazin-1-yl)nitrobenzene

→

5-amino-2-[4-(2-fluoroethyl)-3-oxopiperazin-1-yl]fluorobenzene

Disolventes

ethyl acetate

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solution flushed with argon
2. 2
   workup.ADDITIONPalladium (10% on carbon, 200 mg) is added
3. 3
   Filtraciónthe mixture is filtered through celite and solvent
4. 4
   Otroremoved
5. 5
   Lavadowashed twice with water
6. 6
   Secadodried over magnesium sulfate
7. 7
   Otrothe solvent is removed

Procedimiento

3-Fluoro-4-(4-{2-fluoroethyl}-3-oxopiperazin-1-yl)nitrobenzene (4.35 g) is dissolved in a mixture of ethyl acetate (250 ml) and DMF (5 ml), and the solution flushed with argon. Palladium (10% on carbon, 200 mg) is added and the mixture hydrogenated under ambient pressure. After gas uptake had ceased, the mixture is filtered through celite and solvent removed. The residue is taken up in ethyl acetate, washed twice with water, dried over magnesium sulfate and the solvent is removed to give 5-amino-2-[4-(2-fluoroethyl)-3-oxopiperazin-1-yl]fluorobenzene which is used without further purification.

Fuente