Reacción #1253193

Ecuación de reacción

lauryl alcohol

triethyl amine

p-toluene sulphonyl chloride

→

lauryl tosylate

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe reaction mixture was then washed with 20% sodium chloride solution (500 ml)
2. 2
   SecadoThe washed organic layer was dried over anhydrous sodium sulphate
3. 3
   OtroRemoval of solvent under vacuo
4. 4
   Otroresulted in colorless oil that

Procedimiento

To a stirred and a cooled solution of lauryl alcohol (186.0 g, 1.0 mole) and triethyl amine (121.0 g, 1.2 mole) in dichloromethane (600 ml), p-toluene sulphonyl chloride (228.0 g, 1.2 mole) in dichloromethane (400 ml) was slowly added and the reaction was continued at room temperature for 10 hours. The reaction mixture was then washed with 20% sodium chloride solution (500 ml). The washed organic layer was dried over anhydrous sodium sulphate. Removal of solvent under vacuo resulted in colorless oil that solidified on keeping to yield lauryl tosylate. (309.0 g, 91%), m. p. 29° C. (literature m. p. 29° C.).

Fuente