Reacción #1246187

Ecuación de reacción

2′,6′-Difluoroacetophenone

hydrazine

water

→

title compound

Rendimiento 85.0%

4-fluoro-3-methyl-1H-indazole

Rendimiento 85.0%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroby irradiating microwaves
2. 2
   Otroterminated
3. 3
   Otrothe reaction
4. 4
   Lavadowashed with water
5. 5
   SecadoThe organic layer was dried over anhydrous magnesium sulfate
6. 6
   Concentraciónconcentrated
7. 7
   Otrovacuum evaporation
8. 8
   OtroThe residue was re-crystallized in dichloromethane

Procedimiento

2′,6′-Difluoroacetophenone (0.468 g, 3 mmol) was dissolved in anhydrous hydrazine (2 ml), followed by irradiating microwaves thereon with stirring at 150° C. for 5 min. The addition of water (0.5 ml) at 0° C. terminated the reaction. Afterwards, the reaction solution was diluted with ethyl acetate (10 ml) and washed with water. The organic layer was dried over anhydrous magnesium sulfate and concentrated using vacuum evaporation. The residue was re-crystallized in dichloromethane to give the title compound (Yield 85%).

Fuente