Reacción #1245965

Ecuación de reacción

3-tert-butyl-phenol

2-(2-bromo-ethyl)-[1,3]dioxane

potassium carbonate

→

2-[2-(3-tert-butyl-phenoxy)-ethyl]-[1,3]dioxane

Rendimiento 112.3%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for 16 hours
2. 2
   TemperaturaAfter cooling
3. 3
   Otrothe solvent was removed under reduced pressure
4. 4
   Otrothe residue partitioned between diethyl ether and water
5. 5
   LavadoThe isolated organic layer was washed with water
6. 6
   Secadodried with magnesium sulfate
7. 7
   Filtraciónfiltered
8. 8
   Otrothe solvent removed under reduced pressure

Procedimiento

3-tert-butyl-phenol (1.50 g, 10 mmol), 2-(2-bromo-ethyl)-[1,3]dioxane (1.38 g, 10 mmol) and potassium carbonate (2.15 g, 11 mmol) in 20 ml acetonitrile was heated to reflux for 16 hours. After cooling, the solvent was removed under reduced pressure and the residue partitioned between diethyl ether and water. The isolated organic layer was washed with water, dried with magnesium sulfate, filtered and the solvent removed under reduced pressure to give 2.97 g of crude 2-[2-(3-tert-butyl-phenoxy)-ethyl]-[1,3]dioxane, which was used without further purification.

Fuente