Reacción #1245

Ecuación de reacción

( 17 )

2-amino-4'-fluorobenzophenone

4-fluoroacetophenone

toluene sulfonic acid monohydrate

→

2,4-bis(4-fluorophenyl)quinoline

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroremoved
2. 2
   Temperaturathe mixture is cooled
3. 3
   Otrothe crude solid product is crushed
4. 4
   Lavadowashed with hot ethanol The product
5. 5
   Otrois further recrystallized from toluene

Procedimiento

A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.

Fuente