Reacción #1233

Ecuación de reacción

3-methyl-4-iodobenzoic acid

methanol

sulfuric acid

→

methyl 3-methyl-4-iodobenzoate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated
2. 2
   Temperaturaat reflux for twelve hours
3. 3
   Otrothe reaction medium evaporated
4. 4
   Otrowater, the organic phase decanted off
5. 5
   Secadodried over magnesium sulfate
6. 6
   Otroevaporated
7. 7
   OtroThe residue was triturated in methanol
8. 8
   Filtraciónfiltered
9. 9
   Otro21.9 g (85%) of the expected methyl ester of melting point 58°-59° C. were recovered

Procedimiento

24.4 g (0.093 mol) of 3-methyl-4-iodobenzoic acid and 250 ml of methanol were introduced into a round-bottomed flask and 2.5 ml of concentrated sulfuric acid were added dropwise. The mixture was heated at reflux for twelve hours, the reaction medium evaporated, taken up in ethyl acetate and water, the organic phase decanted off, dried over magnesium sulfate and evaporated. The residue was triturated in methanol and filtered; 21.9 g (85%) of the expected methyl ester of melting point 58°-59° C. were recovered.

Fuente