Reacción #1224

Ecuación de reacción

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

Disolventes

water

ethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction medium evaporated to dryness
2. 2
   Otrothe residue obtained
3. 3
   OtroThe organic phase was decanted off
4. 4
   Secadodried over magnesium sulfate
5. 5
   Otroevaporated
6. 6
   OtroThe residue obtained
7. 7
   Otrowas triturated in heptane
8. 8
   Filtraciónfiltered
9. 9
   Otro4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

Procedimiento

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

Fuente