Reacción #1206

Ecuación de reacción

ethanolamine

1-tetradecyloxy-3-methyl-2-butene oxide

→

title compound

Rendimiento 58.0%

3-(2-hydroxyethylamino)-4-tetradecyloxy-2-methyl-2-butanol

Rendimiento 58.0%

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 100-ml two-necked flask equipped with a stirrer and a dropping funnel
2. 2
   TemperaturaWhile heating
3. 3
   TemperaturaAfter heating
4. 4
   workup.STIRRINGstirring the mixture further for 16 hours
5. 5
   Otrothe resultant reaction mixture
6. 6
   Concentraciónwas concentrated under reduced pressure
7. 7
   Otrothe resultant residue was purified by column chromatography on silica gel

Procedimiento

A 100-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 15.3 g (16.7 mmol) of ethanolamine and 5.0 g of ethanol. While heating and stirring the mixture at 80° C. in a nitrogen atmosphere, an ethanol solution of 5.00 g (16.7 mmol) of 1-tetradecyloxy-3-methyl-2-butene oxide was added dropwise over 3 hours. After heating and stirring the mixture further for 16 hours, the resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 3.47 g (yield: 58%) of the title compound (IIc-4).

Fuente