Reacción #11971

Ecuación de reacción

compound

(2S)-2-(4-(N-Boc-N-2-picolylamino)methylnaphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

hydrochloric acid dioxane

→

hydrochloride

title compound

(2S)-2-(4-(N-2-picolylaminomethyl)naphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the reaction for 3.5 hours
2. 2
   Concentraciónthe reaction solution was concentrated
3. 3
   OtroThe residue obtained
4. 4
   Otrowas purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5)
5. 5
   workup.ADDITIONtreated with hydrochloric acid

Procedimiento

The compound obtained in Example 90-2 (14.2 mg) was dissolved in methanol (0.3 ml), and 4 mol/l hydrochloric acid/dioxane solution (0.3 ml) was added to the solution. After the reaction for 3.5 hours, the reaction solution was concentrated. The residue obtained was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5) and treated with hydrochloric acid to obtain hydrochloride of the title compound (8.1 mg) as a white solid.

Fuente