Reacción #11956

ord-4dc70e910fce4c9ba040b32abaa97152

Ecuación de reacción

CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
compound
CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nα-Fmoc-Nδ-Boc-L-ornithine
CCNCC
diethylamine
→
CC(C)(C)OC(=O)NCCC[C@H](N)C(=O)O
title compound
CC(C)(C)OC(=O)NCCC[C@H](N)C(=O)O
Nδ-Boc-L-ornithine

Reactantes

CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
compound
CC(C)(C)OC(=O)NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nα-Fmoc-Nδ-Boc-L-ornithine
CCNCC
diethylamine

Reactivos

Ninguno

Disolventes

CN(C)C=O
DMF

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroAfter the reaction
  2. 2
    Otrothe solvent was removed by distillation under reduced pressure
  3. 3
    Otrothe residue was dried under vacuum

Procedimiento

The compound obtained in Example 23-1 (250.8 mg) was dissolved in DMF (5 ml). After the addition of diethylamine. (0.5 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation under reduced pressure and the residue was dried under vacuum to obtain the title compound (269.1 mg).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07098215B2uspto-grants-2006_08