Reacción #11954

Ecuación de reacción

compound

Methyl 4-methyl-1-naphthalene Carboxylate

N-bromosuccinimide

azobisisobutylonitrile

→

title compound

Rendimiento 96.6%

Methyl 4-bromomethyl-1-naphthalene Carboxylate

Rendimiento 96.6%

Disolventes

carbontetrachloride

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the completion of the reaction
2. 2
   Otrothe solid was removed
3. 3
   Filtraciónfilter
4. 4
   Concentraciónthe filtrate was concentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in chloroform
6. 6
   Lavadowashed with 1 mol/l aqueous solution of sodium hydroxide and saturated brine
7. 7
   SecadoThe solution was dried over anhydrous sodium sulfate
8. 8
   OtroThe solvent was removed by distillation
9. 9
   Otrothe residue was dried under reduced pressure

Procedimiento

The compound obtained in Example 17-1 (269.9 mg) was dissolved in carbontetrachloride (8 ml), and N-bromosuccinimide (252.6 mg) and azobisisobutylonitrile (22.1 mg) were added to the solution. The mixture was stirred for 6 hours at 70° C. After the completion of the reaction, the solid was removed using a glass filter and the filtrate was concentrated. The residue was dissolved in chloroform and washed with 1 mol/l aqueous solution of sodium hydroxide and saturated brine. The solution was dried over anhydrous sodium sulfate. The solvent was removed by distillation and the residue was dried under reduced pressure to obtain the title compound (363.3 mg) as pale yellow oil.

Fuente