Reacción #1194

Ecuación de reacción

ethanolamine

10-(2-ethylhexyloxy)decyl glycidyl ether

→

title compound

Rendimiento 68.4%

1-(2-hydroxyethylamino)-3-[10-(2-ethylhexyloxy)decyloxy]-2-propanol

Rendimiento 68.4%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 200-ml two-necked flask equipped with a stirrer
2. 2
   Temperaturareflux tube
3. 3
   TemperaturaWhile heating
4. 4
   workup.STIRRINGstirred further for 18 hours
5. 5
   Concentraciónit was concentrated under reduced pressure
6. 6
   Otrothe resultant residue was purified by column chromatography on silica gel

Procedimiento

A 200-ml two-necked flask equipped with a stirrer, reflux tube and dropping funnel was charged with 32.7 g (0.54 mol) of ethanolamine and 10.1 g of ethanol. While heating and stirring the mixture at 80° C., 1.76 g (5.14 mmol) of 10-(2-ethylhexyloxy)decyl glycidyl ether were added dropwise over 2 hours. After the resultant mixture was heated and stirred further for 18 hours, it was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 1.42 g (yield: 68%) of the title compound (Ia-14).

Fuente