Reacción #11825

Ecuación de reacción

2-chloro-1-[4-(4-fluoro-benzyl)-2,5-dimethyl-piperazin-1-yl]-ethanone

4-(5-chloro-2-hydroxy-phenyl)-4-oxo-butyronitrile

potassium carbonate

potassium iodide

→

title compound

Rendimiento 93.8%

4-(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-4-oxo-butyronitrile

Rendimiento 93.8%

Disolventes

Tetrahydrofuran

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrosolids were removed by filtration
2. 2
   ConcentraciónThe filtrate was concentrated
3. 3
   Otrothe crude product purified by flash chromatography

Procedimiento

To a solution of 4-(5-chloro-2-hydroxy-phenyl)-4-oxo-butyronitrile (0.15 g, 0.70 mmol) in acetonitrile (4 mL) was added potassium carbonate (0.16 g, 1.16 mmol), potassium iodide (0.040 g, 0.24 mmol) and (2-chloro-1-[4-(4-fluoro-benzyl)-2,5-dimethyl-piperazin-1-yl]-ethanone (0.21 g, 0.70 mmol). The reaction was stirred for 20 hours at ambient temperature. Tetrahydrofuran (8 mL) was added and solids were removed by filtration. The filtrate was concentrated and the crude product purified by flash chromatography to give the title compound (0.31 g).

Fuente