Reacción #11823

Ecuación de reacción

3-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-3-oxo-propionitrile

sodium bicarbonate

sodium azide

aluminum trichloride

→

title compound

1-(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-2-(1H-tetrazol-5-yl)-ethanone

Disolventes

tetrahydrofuran

dimethylsulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe solution was stirred for 1 hour at ambient temperature
2. 2
   OtroThe solids were removed by filtration
3. 3
   Concentraciónthe filtrate was concentrated in vacuo
4. 4
   OtroThe crude product was purified by reverse phase HPLC

Procedimiento

To a mixture of sodium azide (0.061 g, 0.95 mmol) and aluminum trichloride (0.042 g, 0.31 mmol) was added 3-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-3-oxo-propionitrile (0.035 g, 0.076 mmol) in tetrahydrofuran (2 mL). The reaction was warmed to 70° C. and stirred for 18 hours. To this was added saturated aqueous sodium bicarbonate (0.5 mL) and dimethylsulfoxide (0.5 mL) and the solution was stirred for 1 hour at ambient temperature. The solids were removed by filtration and the filtrate was concentrated in vacuo. The crude product was purified by reverse phase HPLC to give the title compound which was converted to its hydrochloride salt (0.020 g, LRMS: 501.2).

Fuente