Reacción #1178413

Ecuación de reacción

2,2-dimethoxypropane

p-toluenesulfonic acid monohydrate

→

(2,2-dimethyl-[1,3]dioxan-5-yl)-methanol

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   OtroAs much solvent as possible was removed in vacuo
3. 3
   workup.DISTILLATIONthe remainder was purified by distillation under vacuum

Procedimiento

Triol 3-1 (1 eq.) was dissolved in DMF at a concentration of approximately 0.5 M and 2,2-dimethoxypropane (1.16 eq.) and p-toluenesulfonic acid monohydrate (0.03 eq.) were added. The solution was stirred for one or more days, and was quenched with TEA (0.5 eq.). As much solvent as possible was removed in vacuo and the remainder was purified by distillation under vacuum.

Fuente