Reacción #1178396

Ecuación de reacción

HCl

potassium carbonate

diethyl amine

p-bromobenzyl bromide

→

(p-bromobenzyl)diethyl amine

Rendimiento 74.0%

Disolventes

water

water

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   ExtracciónThe mixture was extracted with 100 ml diethyl ether for three times
3. 3
   SecadoThe diethyl ether solution was dried with anhydrous magnesium sulfate over night
4. 4
   Otrothe magnesium sulfate was removed by filtration
5. 5
   OtroDiethyl ether was evaporated
6. 6
   Otrothe raw product was purified by a silica gel column

Procedimiento

Into a 500 ml round-bottomed flask were added 150 ml THF, 5 ml water, 2.2 g potassium carbonate, 6 ml diethyl amine, and 5 g p-bromobenzyl bromide. The resultant mixture was refluxed for 12 h. The mixture was then cooled to room temperature, into which 6 ml concentrated HCl was added, followed by the addition of 150 ml water. The mixture was extracted with 100 ml diethyl ether for three times. The diethyl ether solution was dried with anhydrous magnesium sulfate over night and then the magnesium sulfate was removed by filtration. Diethyl ether was evaporated and the raw product was purified by a silica gel column using hexane/chloroform mixture (1:1 by volume) as the eluent. (p-bromobenzyl)diethyl amine (BBDA) was obtained in 74% yield (3.6 g).

Fuente