Reacción #1178207

Ecuación de reacción

benzamide

N-[[[2-(aminocarbonyl)phenyl]amino]thioxomethyl]-4-chlorobenzamide

ammonia

hydrogen peroxide

→

desired product

Rendimiento 47.9%

4-Chloro-N-(1,4-Dihydro-4-oxo-2-quinazolinyl)benzamide

Rendimiento 47.9%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solid was collected
2. 2
   workup.DISSOLUTIONpartially dissolved in 500 ml of hot acetonitrile
3. 3
   OtroThe undissolved solid was collected
4. 4
   workup.ADDITIONmixed with 100 ml of hot water
5. 5
   Otrothe solid collected

Procedimiento

To a stirred mixture of 10 g of the above benzamide, 100 ml of methanolic ammonia and 100 ml of methanol was added dropwise 25 ml of 30% hydrogen peroxide, during 10 minutes. The mixture was stirred overnight, the solid was collected, and then partially dissolved in 500 ml of hot acetonitrile. The undissolved solid was collected, mixed with 100 ml of hot water and the solid collected, giving 4.3 g of the desired product as off-white crystals, mp 239°-241° C. (dec.).

Fuente