Reacción #1178203

Ecuación de reacción

benzamide

N-[[[2-(aminocarbonyl)phenyl]amino]thioxomethyl]-4-methoxybenzamide

ammonia

hydrogen peroxide

→

desired product

Rendimiento 10.7%

N-(1,4-Dihydro-4-oxo-2-quinazolinyl)-4-methoxybenzamide

Rendimiento 10.7%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was cooled because of an exotherm
2. 2
   OtroThe solid was collected
3. 3
   workup.DISSOLUTIONpartially dissolved in 800 ml of acetonitrile
4. 4
   Filtraciónfiltered
5. 5
   TemperaturaThe filtrate was chilled

Procedimiento

To a stirred mixture of 9.9 g of the above benzamide, 100 ml of methanolic ammonia and 100 ml of methanol was added 22 ml of 30% hydrogen peroxide. The reaction was cooled because of an exotherm and then stirred overnight at room temperature. The solid was collected, partially dissolved in 800 ml of acetonitrile and filtered. The filtrate was chilled, giving 0.95 g of the desired product as white crystals, mp 235°-236° C. (dec.).

Fuente