Reacción #1178201

Ecuación de reacción

methanol

benzamide

N-[[[2-(aminocarbonyl)phenyl]amino]thioxomethyl]benzamide

hydrogen peroxide

→

desired product

Rendimiento 40.1%

N-(1,4-Dihydro-4-oxo-2-quinazolinyl)benzamide

Rendimiento 40.1%

Disolventes

ammonia

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   Otrothe solid collected
3. 3
   workup.DISSOLUTIONpartially dissolved in 500 ml of hot acetonitrile
4. 4
   Filtraciónfiltered
5. 5
   TemperaturaThe filtrate was chilled
6. 6
   Otrothe solid collected

Procedimiento

To a stirred mixture of 4.5 g of the above benzamide in a mixture of 120 ml of methanolic ammonia plus 100 ml of methanol, was added dropwise, 3.6 ml of 30% hydrogen peroxide. This mixture was stirred overnight, the solid collected, partially dissolved in 500 ml of hot acetonitrile and filtered. The filtrate was chilled and the solid collected, giving 1.6 g of the desired product as white crystals, mp 227°-228° C. (dec.).

Fuente