Reacción #11765

Ecuación de reacción

(5-chloro-2-methoxy-phenyl)-methanesulfonamide

boron tribromide

→

title compound

Rendimiento 86.8%

(5-Chloro-2-hydroxy-phenyl)-methanesulfonamide

Rendimiento 86.8%

Disolventes

dichloroethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was quenched with water, saturated with sodium chloride
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   SecadoThe organic layer was dried over sodium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

To a suspension of (5-chloro-2-methoxy-phenyl)-methanesulfonamide (0.03 g, 0.13 mmol) in dichloroethane (1.5 mL) was added boron tribromide solution (1M in dichloromethane, 0.26 mL, 0.26 mmol). The reaction was stirred for one hour at ambient temperature. The reaction was quenched with water, saturated with sodium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to give the title compound (0.025 g).

Fuente