Reacción #1173702

ord-7bf9697d0616420c85c3b2af21eb3d1c

Ecuación de reacción

COC(=O)Cc1ccc2c(c1)CC(N)C2.Cl
methyl (2-aminoindan-5-yl)acetate hydrochloride
O=S(=O)(Cl)c1ccc(Cl)cc1
4-chlorophenylsulfonyl chloride
CNCC(=O)OC.Cl
methyl N-methyl-glycinate hydrochloride
→
CN(CC(=O)O)C(=O)Cc1ccc2c(c1)CC(NS(=O)(=O)c1ccc(Cl)cc1)C2
2-[N-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetyl-N-methylamino]-acetic acid

Reactantes

COC(=O)Cc1ccc2c(c1)CC(N)C2.Cl
methyl (2-aminoindan-5-yl)acetate hydrochloride
O=S(=O)(Cl)c1ccc(Cl)cc1
4-chlorophenylsulfonyl chloride
CNCC(=O)OC.Cl
methyl N-methyl-glycinate hydrochloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    workup.ADDITIONare treated

Procedimiento

In the same manner as described in Examples 24 and 33, methyl (2-aminoindan-5-yl)acetate hydrochloride, 4-chlorophenylsulfonyl chloride and methyl N-methyl-glycinate hydrochloride are treated to give 2-[N-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetyl-N-methylamino]-acetic acid

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05030652uspto-grants-1991_07