Reacción #11720

Ecuación de reacción

(2R)-2-methyl-piperizine

4-fluorobenzyl chloride

sodium hydrogen carbonate

→

title compound

Rendimiento 53.3%

(3R)-1-(4-Fluoro-benzyl)-3-methyl-piperazine

Rendimiento 53.3%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was refluxed overnight
2. 2
   Temperaturacooled
3. 3
   Concentraciónconcentrated
4. 4
   workup.ADDITIONThe remaining residue was diluted with dichloromethane
5. 5
   Lavadowashed with water
6. 6
   OtroThe organic layer was separated
7. 7
   Concentraciónconcentrated
8. 8
   Otroto give a clear oil

Procedimiento

To a solution of (2R)-2-methyl-piperizine (4.5 g, 45 mmol) in ethanol (80 mL) was added 4-fluorobenzyl chloride (5.38 mL, 45.0 mmol) and sodium hydrogen carbonate (11.3 g, 135 mmol). The reaction was refluxed overnight, cooled and concentrated. The remaining residue was diluted with dichloromethane and washed with water. The organic layer was separated and concentrated to give a clear oil. Chromatography on silica gel gave the title compound (5.0 g).

Fuente