Reacción #1171

Ecuación de reacción

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

Rendimiento 35.0%

Disolventes

EtOAc

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with 1N aq. HCl, 5N aq. NaOH
2. 2
   Secadodried over MgSO4
3. 3
   Concentraciónconcentrated

Procedimiento

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

Fuente