Reacción #11709

Ecuación de reacción

hydrochloric acid

sodium hydroxide

4-chloro-2-methoxy-phenol

chloroacetic acid

→

title compound

Rendimiento 120.0%

(4-Chloro-2-methoxy-phenoxy)-acetic acid

Rendimiento 120.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool to ambient temperature
2. 2
   Extracciónextracted with diethyl ether
3. 3
   SecadoThe organic layer was dried over magnesium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated in vacuo

Procedimiento

To a solution of sodium hydroxide (6.6 g, 160 mmol) in water (45 mL) was added 4-chloro-2-methoxy-phenol (2.0 mL, 16 mmol) and chloroacetic acid (7.7 g, 81 mmol). The resulting mixture was heated to 95° C. and stirred for three hours. The reaction was allowed to cool to ambient temperature and slowly acidified with concentrated hydrochloric acid (10 mL) until the mixture became a solution and then extracted with diethyl ether. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo to give the title compound (4.16 g).

Fuente